Prednisone Review and side effects
Immunosuppression refers to an action that reduces the efficiency of immune system. This technique used in the treatment of several medical conditions. Sometimes this intentionally introduced to prevent the immune system to reject human organ transplant which otherwise make it impossible to successfully transplant. Prednisone is synthetically produced cortisteroid to effect immunosuppression. The main disadvantage is that the drug by reducing the action of immune system makes the patient vulnerable to many infectious diseases. Prednisone is used to combat certain inflammatory diseases and some types of cancer with high doses of the drug.
Prednixone was first isolated and the structure studies in 1954 by Hershal Herzog. And Schering Corporation first synthesised the product in 1955. The effect of the drug was demonstrated to have effects of enhanced activity of adrenocorticoid. The drug was released in market in 1960 under the trade name under the m name Meticorten and Meticortelone.
Though Prednsone can be taken orally, it also can be administered as intramuscular (IM) or intravenous (IV) injection. The active ingredient is called Prednisolone which is a steroid.
Uses of Prednsone:
It is administered for various conditions such as asthma, rheumatic disorders COPD (Chronic Obstructive Pulmonary Disease), allergic disorders, adreno-cortical insufficiency, cancer induced hypercalcemia, thyrodoitis, advanced tuberculosis and host of other diseases. It is also given as a treatment of migraine headaches and aphthous ulcers. It is a part of the administration of medication intended to prevent the rejection after organ transplant.
Side effects of Prednisone:
Like all glucocorticoids it induces high blood glucose and the effect is more severe in patients with diabetes mellitus or under the medication which are known to increase blood glucose. There are other short effects like conditions called mineralocorticoid effects seen by fluid retention, insomnia, euphoria, and even mania. The effect of weakening immune system will make the patient susceptible to all kind of infections. This calls for extra protection from getting in contact with persons carrying any infectious diseases when the patient is on Prednislne regime. The conditions can be severe and fatal also.
Long term effects of Prednisone are of more serious nature. They include truncal weight increase, type II diabetes mellitus, Cushing’s syndrome, osteoporosis, cataracts, glaucoma and depression.
Other major side effects observed are increase in blood sugar levels in diabetic patients, difficulty in control of emotions, disturbances seen in mental efficacy, gain of weight, swelling of face, depression and mania. Other serious conditions are extreme fatigue, vision impairment, pain in body joints like hips and shoulder, long term migraine, ulcers, insomnia, over all pains in joints, anxiety and osteoporosis etc.
Development of Dependency of the drug:
If the medicine is administered for more than seven days Adrenal suppression will occur. This may ultimately result in body loosing ability to produce corticosteroids and will create dependency on Prednisone and this has to be taken into consideration while giving this drug.
The drug is offered under the prescription of a medical practitioner only.
It is available at price of about USD 8 to USD 10 for 100 count pills of 20 mg.
Prednisone is used to treat the diseases or their symptoms caused by low level of corticosteroids or some other conditions of people whose level of corticosteroids is normal. These are the cases of arthritis (certain types), allergic reactions (severe cases), multiple sclerosis (when the functions of nerves are not proper), lupus (a condition when the organs are attacked by the organism) and some other conditions effecting lungs, eyes, skin, kidney’s blood, stomach, thyroid and intenstines. Cancer of some certain types are also sometimes treated with Prednisone. Prednisone refers to the corticosteroids class of medications. It replaces the coticosteroids within a human body which must be normally and naturally produced by the organism. Prednisone may come as a solution (liquid), a tablet or a concentrated solution and is taken by mouth. Your dosage and the schedule if taking the medicine will be provided by your doctor and will depend on the results of treatment. Take the cure just the way your doctor tells you, not more or lees as prescribed. The concentrated Prednisone solution is taken using the special dropper which comes in the package. The concentrated Prednisone solution may be mixed with flavored liquids (juice). Your personal doctor can change your dosage of Prednisone during the treatment to make sure that your dose is the lowest dose possible working. The dosage may also be changed if you go through a surgery, infection, illness or a serious asthma attack. Remember to tell your personal doctor if you achieve any changes in your symptoms during taking Prednisone. Don’t stop taking the medication even if you feel much better and never stop taking it without telling your doctor as it may cause extreme tiredness, weakness, changes in skin color, mouth sores, craving for salt, slowed movements, upset stomach, weight loss. Remember telling your doctor about any allergy you have to Prednisone.